1.

Buffalo Sabres
 vs. Philadelphia Flyers

October 3, 2010
Sunday, 6:00 pm

 2.

Buffalo Sabres
 vs. New York Rangers

October 9, 2010
Saturday, 7:00 pm

 3.

Buffalo Sabres
 vs. Chicago Blackhawks

October 11, 2010
Monday, 7:00 pm

 4.

Buffalo Sabres
 vs. New Jersey Devils

October 13, 2010
Wednesday, 7:00 pm

 5.

Buffalo Sabres
 vs. Montreal Canadiens

October 15, 2010
Friday, 7:30 pm

 6.

Buffalo Sabres
 vs. Ottawa Senators

October 22, 2010
Friday, 7:30 pm

 7.

Buffalo Sabres
 vs. Boston Bruins

November 3, 2010
Wednesday, 7:00 pm

 8.

Buffalo Sabres
 vs. Montreal Canadiens

November 5, 2010
Friday, 7:30 pm

 9.

Buffalo Sabres
 vs. Washington Capitals

November 13, 2010
Saturday, 7:00 pm

 10.

Buffalo Sabres
 vs. Vancouver Canucks

November 15, 2010
Monday, 7:00 pm

 11.

Buffalo Sabres
 vs. Los Angeles Kings

November 19, 2010
Friday, 7:30 pm

 12.

Buffalo Sabres
 vs. Tampa Bay Lightning

November 20, 2010
Saturday, 7:00 pm

 13.

Buffalo Sabres
 vs. Pittsburgh Penguins

November 24, 2010
Wednesday, 7:00 pm

 14.

Buffalo Sabres
 vs. Toronto Maple Leafs

November 26, 2010
Friday, 7:30 pm

 15.

Buffalo Sabres
 vs. Columbus Blue Jackets

December 3, 2010
Friday, 7:30 pm

 16.

Buffalo Sabres
 vs. San Jose Sharks

December 9, 2010
Thursday, 7:00 pm

 17.

Buffalo Sabres
 vs. Pittsburgh Penguins

December 11, 2010
Saturday, 7:00 pm

 18.

Buffalo Sabres
 vs. Boston Bruins

December 15, 2010
Wednesday, 7:00 pm

 19.

Buffalo Sabres
 vs. Anaheim Ducks

December 21, 2010
Tuesday, 7:00 pm

 20.

Buffalo Sabres
 vs. Florida Panthers

December 23, 2010
Thursday, 7:00 pm

 21.

Buffalo Sabres
 vs. Boston Bruins

January 1, 2011
Saturday, 5:00 pm

 22.

Buffalo Sabres
 vs. Philadelphia Flyers

January 11, 2011
Tuesday, 7:00 pm

 23.

Buffalo Sabres
 vs. Carolina Hurricanes

January 13, 2011
Thursday, 7:00 pm

 24.

Buffalo Sabres
 vs. Montreal Canadiens

January 18, 2011
Tuesday, 7:00 pm

 25.

Buffalo Sabres
 vs. New York Islanders

January 21, 2011
Friday, 7:30 pm

 26.

Buffalo Sabres
 vs. Toronto Maple Leafs

February 5, 2011
Saturday, 7:00 pm

 27.

Buffalo Sabres
 vs. New York Islanders

February 13, 2011
Sunday, 3:00 pm

 28.

Buffalo Sabres
 vs. Toronto Maple Leafs

February 16, 2011
Wednesday, 7:00 pm

 29.

Buffalo Sabres
 vs. St. Louis Blues

February 18, 2011
Friday, 7:30 pm

 30.

Buffalo Sabres
 vs. Washington Capitals

February 20, 2011
Sunday, 3:00 pm

 31.

Buffalo Sabres
 vs. Atlanta Thrashers

February 23, 2011
Wednesday, 7:00 pm

 32.

Buffalo Sabres
 vs. Ottawa Senators

February 25, 2011
Friday, 7:30 pm

 33.

Buffalo Sabres
 vs. Detroit Red Wings

February 26, 2011
Saturday, 7:00 pm

 34.

Buffalo Sabres
 vs. Ottawa Senators

March 13, 2011
Sunday, 5:00 pm

 35.

Buffalo Sabres
 vs. Carolina Hurricanes

March 15, 2011
Tuesday, 7:00 pm

 36.

Buffalo Sabres
 vs. Atlanta Thrashers

March 19, 2011
Saturday, 7:00 pm

 37.

Buffalo Sabres
 vs. Nashville Predators

March 20, 2011
Sunday, 5:00 pm

 38.

Buffalo Sabres
 vs. Florida Panthers

March 25, 2011
Friday, 7:30 pm

 39.

Buffalo Sabres
 vs. New Jersey Devils

March 26, 2011
Saturday, 7:00 pm

 40.

Buffalo Sabres
 vs. New York Rangers

March 30, 2011
Wednesday, 7:00 pm

 41.

Buffalo Sabres
 vs. Tampa Bay Lightning

April 5, 2011
Tuesday, 7:00 pm

 42.

Buffalo Sabres
 vs. Philadelphia Flyers

April 8, 2011
Friday, 7:30 pm