1.

Pittsburgh Penguins
 vs. Detroit Red Wings

September 22, 2010
Wednesday, 7:00 pm

 2.

Pittsburgh Penguins
 vs. Columbus Blue Jackets

September 25, 2010
Saturday, 7:00 pm

 3.

Pittsburgh Penguins
 vs. Chicago Blackhawks

September 28, 2010
Tuesday, 7:00 pm

 4.

Pittsburgh Penguins
 vs. Philadelphia Flyers

October 7, 2010
Thursday, 7:00 pm

 5.

Pittsburgh Penguins
 vs. Montreal Canadiens

October 9, 2010
Saturday, 7:00 pm

 6.

Pittsburgh Penguins
 vs. Toronto Maple Leafs

October 13, 2010
Wednesday, 7:30 pm

 7.

Pittsburgh Penguins
 vs. New York Islanders

October 15, 2010
Friday, 7:00 pm

 8.

Pittsburgh Penguins
 vs. Ottawa Senators

October 18, 2010
Monday, 7:00 pm

 9.

Pittsburgh Penguins
 vs. Philadelphia Flyers

October 29, 2010
Friday, 7:00 pm

 10.

Pittsburgh Penguins
 vs. Boston Bruins

November 10, 2010
Wednesday, 7:00 pm

 11.

Pittsburgh Penguins
 vs. Tampa Bay Lightning

November 12, 2010
Friday, 7:00 pm

 12.

Pittsburgh Penguins
 vs. New York Rangers

November 15, 2010
Monday, 7:00 pm

 13.

Pittsburgh Penguins
 vs. Vancouver Canucks

November 17, 2010
Wednesday, 7:00 pm

 14.

Pittsburgh Penguins
 vs. Carolina Hurricanes

November 19, 2010
Friday, 7:00 pm

 15.

Pittsburgh Penguins
 vs. Ottawa Senators

November 26, 2010
Friday, 1:00 pm

 16.

Pittsburgh Penguins
 vs. Calgary Flames

November 27, 2010
Saturday, 1:00 pm

 17.

Pittsburgh Penguins
 vs. Atlanta Thrashers

December 2, 2010
Thursday, 7:00 pm

 18.

Pittsburgh Penguins
 vs. New Jersey Devils

December 6, 2010
Monday, 7:00 pm

 19.

Pittsburgh Penguins
 vs. Toronto Maple Leafs

December 8, 2010
Wednesday, 7:00 pm

 20.

Pittsburgh Penguins
 vs. New York Rangers

December 15, 2010
Wednesday, 7:00 pm

 21.

Pittsburgh Penguins
 vs. Phoenix Coyotes

December 20, 2010
Monday, 7:00 pm

 22.

Pittsburgh Penguins
 vs. Florida Panthers

December 22, 2010
Wednesday, 7:00 pm

 23.

Pittsburgh Penguins
 vs. Atlanta Thrashers

December 28, 2010
Tuesday, 7:00 pm

 24.

Pittsburgh Penguins
 vs. Washington Capitals

January 1, 2011
Saturday, 1:00 pm

 25.

Pittsburgh Penguins
 vs. Tampa Bay Lightning

January 5, 2011
Wednesday, 7:00 pm

 26.

Pittsburgh Penguins
 vs. Minnesota Wild

January 8, 2011
Saturday, 7:00 pm

 27.

Pittsburgh Penguins
 vs. Boston Bruins

January 10, 2011
Monday, 7:00 pm

 28.

Pittsburgh Penguins
 vs. Detroit Red Wings

January 18, 2011
Tuesday, 7:00 pm

 29.

Pittsburgh Penguins
 vs. Carolina Hurricanes

January 22, 2011
Saturday, 7:00 pm

 30.

Pittsburgh Penguins
 vs. New York Islanders

January 25, 2011
Tuesday, 7:00 pm

 31.

Pittsburgh Penguins
 vs. New York Islanders

February 2, 2011
Wednesday, 7:00 pm

 32.

Pittsburgh Penguins
 vs. Buffalo Sabres

February 4, 2011
Friday, 7:00 pm

 33.

Pittsburgh Penguins
 vs. Columbus Blue Jackets

February 8, 2011
Tuesday, 7:00 pm

 34.

Pittsburgh Penguins
 vs. Los Angeles Kings

February 10, 2011
Thursday, 7:00 pm

 35.

Pittsburgh Penguins
 vs. Washington Capitals

February 21, 2011
Monday, 7:00 pm

 36.

Pittsburgh Penguins
 vs. San Jose Sharks

February 23, 2011
Wednesday, 7:00 pm

 37.

Pittsburgh Penguins
 vs. Buffalo Sabres

March 8, 2011
Tuesday, 7:00 pm

 38.

Pittsburgh Penguins
 vs. Montreal Canadiens

March 12, 2011
Saturday, 2:00 pm

 39.

Pittsburgh Penguins
 vs. Edmonton Oilers

March 13, 2011
Sunday, 1:00 pm

 40.

Pittsburgh Penguins
 vs. New York Rangers

March 20, 2011
Sunday, 12:30 pm

 41.

Pittsburgh Penguins
 vs. New Jersey Devils

March 25, 2011
Friday, 7:00 pm

 42.

Pittsburgh Penguins
 vs. Florida Panthers

March 27, 2011
Sunday, 1:00 pm

 43.

Pittsburgh Penguins
 vs. Philadelphia Flyers

March 29, 2011
Tuesday, 7:00 pm

 44.

Pittsburgh Penguins
 vs. New Jersey Devils

April 5, 2011
Tuesday, 7:00 pm